About the centre

A joint research centre between Murdoch University and the Perron Institute, the Centre for Molecular Medicine and Innovative Therapeutics (CMMIT) brings together researchers and specialist clinicians from a range of disciplines who have a common focus on developing precision medicine solutions to combat diseases affecting society today.

Our researchers believe precision medicine has the potential to transform healthcare on a scale equivalent to the way antibiotics transformed the fight against infectious diseases.

The centre’s core research areas

Research groups within CMMIT are working on topics as diverse as genetic therapies, genomics. motor neurone disease, neurodegenerative disorders, including Parkinson’s disease, myositis, multiple sclerosis, cognition and exercise, health economics, sepsis, mathematical modelling of biological processes and wound healing.

Established in 2019, CMMIT has made substantial progress towards its long-term goal of evolving into multi-disciplinary research centre with the range of skills to enable it to address some of the bigger issues facing healthcare today.

CMMIT aims to be adaptable responding to needs as they change. This is reflected in the success of multiple COVID-19 projects that have led to new screening techniques and new therapeutic approaches.

 

molecular therapy researchers

Molecular Therapy

Professor Steve Wilton and Dr May Aung-Htut lead a group that focuses on developing novel therapeutic strategies to treat rare inherited or the much more common acquired human diseases by designing genetic drugs (antisense oligonucleotides) to modify gene expression as necessary: suppressing or by-passing disease-causing mutations, switching isoforms or increasing expression.

Rakesh Veedu looking into machine

Precision Nucleic Acid

Therapeutics Associate Professor Rakesh Veedu leads the development of novel therapeutic molecules that facilitate target-specific delivery of drugs or diagnostics to specific disease sites in the body.

Professor Akkari and team

Motor Neurone Disease

Professor Anthony Akkari and team are investigating new approaches to the treatment of the fatal motor neurone disease (MND), a disease affecting 350,000 people worldwide.

researcher talking to male patient

Neurodegenerative Diseases (including Parkinson's Disease)

Professor Sulev Kõks and his team aim to probe the genetics and molecular pathology of Parkinson’s Disease – with the goal of improving the precision clinical management of patients.

professor examines woman

Myositis

Professor Merrilee Needham and her team are investigating the treatment, genetics and immuno-pathology of immune-mediated myositis, particularly inclusion body myositis.

researcher with 2 students

Clinical Exercise and Cognition

Dr Yvonne Learmonth leads an experienced team of researchers in the fields of biomechanics, physiology, motor control and cognition to promote the development of precision therapies.

Professor Kermode in lab

Demyelinating Diseases Group (including Multiple Sclerosis)

Clinical Professor Allan Kermode and his team explore the clinical, laboratory, radiological, and immunogentic aspects of multiple sclerosis and related disorders, which affect over 25,000 Australians.

Dr Rea in lab

Functional Genomics

Dr Sarah Rea investigates the functional consequences of genetic changes that are associated with neurodegenerative diseases such as ALS and Dementia and aims to identify novel therapeutic strategies to combat these diseases.

researchers laughing

Oligo Therapeutics

Following the global breakthrough she and Professor Steve Wilton pioneered, developing compounds to treat Duchenne muscular dystrophy as well as a range of other rare disorders, Professor Fletcher and her team research into inherited blindness and neurodegenerative diseases.

cell tissues lab

Cell-Tissue Systems Modelling

Professor Bruce Gardiner’s research uses computational and mathematical models to integrate the physical, chemical and biological processes underlying diseases such as osteoarthritis, colorectal cancer, acute kidney injury and glaucoma.

Dr Currie and researcher

Sepsis Diagnostic Research

Dr Andrew Currie leads a collaborative team of clinicians, veterinarians and medical researchers invested in finding new and better ways to diagnose, treat and prevent sepsis in newborns, adults and companion animals.

laptop screen with data

Economic Evaluation of Disease & Diagnostics

Associate Professor Khurshid Alam leads a group in the field of health economics and health care financing research in Murdoch where they conduct cost-effectiveness and cost-benefit analysis to examine value for money (VfM) and resource-allocation for clinical, laboratory and public health interventions.

close up of knee caps

Skin Integrity

Skin Integrity Research Group led by Associate Professor Kylie Sandy-Hodgetts research focuses on the clinical prevention and early identification of surgical wound complications such as surgical site infection and surgical wound dehiscence. The programme includes Phase 1-IV clinical trials, comparative effectiveness studies, validation of diagnostic methods for identification and classification of wound infection, and the development of AI tools to predict at risk patient groups.

sequencing machine

Drug Hypersensitivity

Professor Elizabeth Phillips and Dr Andrew Gibson lead research to identify and validate novel genetic-, cellular-, and structural-risk factors to predict and prevent life-threatening adverse drug reactions.

Key researchers

Professor Steve Wilton

Professor Steve Wilton AO

Centre Director

dr khurshid alam

Associate Professor Khurshid Alam

Researcher

anthony-akkarI

Professor Anthony Akkari

Researcher

dr may aung htut

Dr May Aung-Htut

Researcher

dr andrew currie

Dr Andrew Currie

Researcher

sue-fletcher-web

Professor Sue Fletcher AO

Researcher

bruce-gardner

Professor Bruce Gardiner

Researcher

sandy hodgetts

Associate Professor Kylie Sandy-Hodgetts

Researcher

allan-kermode

Clinical Professor Allan Kermode

Researcher

sulev-koks

Professor Sulev Kõks

Researcher

yvonne-learmonth

Dr Yvonne Learmonth

Researcher

merrilee-needham

Professor Merrilee Needham

Researcher

sarah-rea-web

Dr Sarah Rea

Researcher

rakesh-veedu

Associate Prof. Rakesh Veedu

Researcher

Latest news from the centre

Looking for postgraduate study research opportunities?

You can apply for a research degree at any time during the year. To learn more about our research areas, supervisors and project opportunities, see the brochure below:

Annual reports

To learn more about the centres' research, view our Annual Reports.