Australian National Phenome Centre
Delivering on Murdoch’s mission to change lives and solve problems of global significance.
Revolutionary research that will transform the health and lives of billions
The Australian National Phenome Centre (ANPC), led by Murdoch University, will transform how long and how well people live, not just in Australia, but around the world.
World-leading researchers at the ANPC plan to revolutionise the diagnosis, prevention and treatment of serious health challenges like cancer, Alzheimer’s, autism, obesity and Type 2 diabetes.
By analysing the molecular, physical and biochemical characteristics of biological tissue and fluids such as blood and urine, researchers at the ANPC aim to predict the complex genetic, environmental and lifestyle interactions causing disease.
The work of the ANPC supports almost every area of bioscience. It reaches across traditional research silos and fosters a new, more collaborative approach to science. Long-term, the ANPC hopes to build ‘global atlases’ of human disease, providing insights into future health risks which everyone on the planet can benefit from.
The only facility of its kind in the southern hemisphere, the ANPC brings together all five Western Australian universities and leading health and medical research institutes. It is linked to the International Phenome Centre Network and also has wide applications in agriculture and environmental science.
The ANPC will position Perth and WA as a global leader in precision medicine, and enable quantum leaps in predicting, diagnosing and treating disease.
A guide to phenomes and phenomics
A person's phenome is a dynamic fingerprint of their unique biology resulting from the complex interactions between environmental and genetic factors.
Phenomics is the study of how the environment and a person’s lifestyle interacts with their genes to influence their health and risk of disease.
Metabolic phenotyping is the analysis of biological tissue and fluid to uncover the specific interactions of genetic, environmental and lifestyle factors at a molecular level.
The work of the ANPC will enable doctors to classify patients into groups to better identify and predict the drugs that will work best for each individual.
Doctors will be able to identify differences in biological factors that might help them predict if a cancer is likely to spread in a particular individual.
ANPC research will help doctors explain to patients how their lifestyle choices such as poor diet and lack of exercise are affecting their body’s current and future health.
Phenomics studies will reveal how genetic, dietary, environmental and lifestyle factors contribute to poorer health outcomes in Aboriginal communities.
Phenomics can also help researchers address crop disease, biosecurity and food safety.
Population-sized studies will reveal how human health may be impacted by environmental and cultural factors.
An internationally renowned pioneer in metabolic phenotyping and systems medicine, Professor Nicholson will be leading the ANPC. He currently holds the appointment of Pro Vice Chancellor for the Health Future Institute at Murdoch University. He is a Highly Cited Scholar who has published more than 600 peer-reviewed papers on molecular aspects of body systems medicine. A Fellow of the UK Academy of Medical Science, Professor Nicolson comes to WA from Imperial College London where he was the founding director of the MRC-NIHR National Phenome Centre.
A distinguished computational biologist and Highly Cited Scholar, Professor Holmes has been appointed the 2018 WA Premier’s Fellow in Phenomics. She will be progressing research on maternal and infant health, liver and gastrointestinal disease and metabolic diseases such as diabetes, and dementia. She is a Fellow of the UK Academy of Medical Sciences, and was Head of the Division of Computational and Systems Medicine at Imperial College London.
Associate ProfessorRobert Trengove
Professor Trengove is the founder and director of the Separation Science and Metabolomics Lab at Murdoch and leads an experienced team of metabolomics researchers with interests in medicine and health, focusing on the nexus between environment and health, food security, grains and agriculture. He has been instrumental in the establishment of the ANPC.
DoctorRuey Leng Loo
Dr Loo has been appointed the 2018 WA Premier’s Early to Mid-Career Fellow. She has specific research interests in the influence of diet and nutrition on human metabolism and the gut microbiome. She and Professor Holmes have been research collaborators since Professor Holmes was one of her PhD supervisors.
Through its global connections, the ANPC will participate in multi-centre, large-scale metabolic phenotyping studies into a range of diseases and health issues including diabetes, autism, antimicrobial resistance and cancer, to gain insights into the environmental, genetic and social factors influencing development and expression of these conditions.
Research at the ANPC is connected with work at similar centres across the International Phenome Centre Network, including sites in London, Birmingham, Hong Kong and Singapore, supported by Bruker Biospin and Bruker Daltonics. This collaboration will progress the global understanding of how diverse environmental and cultural conditions affect a range of serious diseases and conditions.
Professor David Morrison
Deputy Vice Chancellor (Research & Innovation)
+61 8 9360 6788
Australian National Phenome Centre (ANPC)
Murdoch University, Perth campus
90 South Street, Murdoch, Western Australia 6150