Australian National Phenome Centre

Changing lives and solving problems of global significance

The work of the ANPC supports almost every area of bioscience. It reaches across traditional research silos and fosters a new, more collaborative approach to science that is critical to solving some of the world’s most challenging problems.

As the international centre of expertise in metabolic phenotyping, the ANPC provides an important new platform for research across the full spectrum of health, food and the environment.

 

News from the Institute

Revolutionary research that will transform the health and lives of billions

By analysing the molecular, physical and biochemical characteristics of biological tissue and fluids such as blood and urine, researchers at the ANPC aim to predict the complex genetic, environmental and lifestyle interactions causing disease.

Core research areas

female researcher handling research equipment

Precision medicine

Phenomics will enable doctors to deliver precision medicine by predicting the likelihood of disease or characterising its progression, ensuring patients receive treatments tailored to their need.

By studying the phenotypes of different populations, researchers will learn more about the causes and best treatments for a range of complex diseases such as diabetes, autism, antimicrobial resistance to antibiotics, and cancer.

indigenous mother and baby

Indigenous health

Phenomics studies will help researchers better understand genetic, dietary, environmental and lifestyle factors that contribute to poorer health outcomes in Aboriginal communities.

This research will help develop and assess the effectiveness of interventions to address these factors and strengthen the health of the population.

handful of wheat grains

Precision Nutrition and Food

Our analysis of population samples will reveal how human health is affected by the nutritional quality and density of food, which will lead the development of nutritional and clinical stratification frameworks through the study of gut microbiome-host-diet interactions.

We are collaborating with researchers around the world to better understand individual responses to diet by coupling data from highly-controlled dietary studies with deep metabolic phenotyping, with the aim of personalizing healthy eating advice.

Excellence in research: Our people

Professor Jeremy Nicholson

An internationally-renowned pioneer in metabolic phenotyping and systems medicine, Professor Nicholson is the Pro Vice Chancellor for Health Sciences at Murdoch University and a Clarivate Analytics Highly Cited Researcher who has authored more than 700 peer-reviewed papers on molecular aspects of body systems medicine.

A Fellow of the UK Academy of Medical Science, Professor Nicholson comes to WA from Imperial College London where he was the founding director of the MRC-NIHR National Phenome Centre.

Professor Elaine Holmes

A distinguished computational biologist, Professor Holmes is Director of the Centre for Computational and Systems Medicine and Deputy Director of the ANPC.

As the Western Australian Premier’s Fellow for Phenomics and Australian Laureate Fellow, Professor Holmes pioneers computational approaches to biomarker discovery by integrating multi-modal data associated with gene-environment interactions.

She is progressing research on maternal and infant health, liver and gastrointestinal disease and metabolic diseases such as diabetes and dementia.

 

A guide to phenomes and phenomics

phenome

Phenome

A person's phenome is a dynamic fingerprint of their unique biology resulting from the complex interactions between environmental and genetic factors.

phenomics

Phenomics

Phenomics is the study of how a person’s lifestyle and environment interacts with their genes to influence their health and risk of disease.

metabolic phenotyping

Metabolic phenotyping

Metabolic phenotyping is the analysis of biological tissue and fluid to uncover the specific interactions of genetic, environmental and lifestyle factors at the molecular level.

 
 

Recent Papers

Published: 27 August 2020

Quantitative In-Vitro Diagnostic NMR Spectroscopy for Lipoprotein and Metabolite Measurements in Plasma and Serum: Recommendations for Analytical Artefact Minimization with Special Reference to COVID-19/SARS-CoV-2 Samples

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Published: 20 August 2020

Improved Spatial Resolution of Metabolites in Tissue Biopsies Using High-Resolution Magic-Angle-Spinning Slice Localization NMR Spectroscopy

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Published: 17 August 2020

Integrative Modelling of Quantitative Plasma Lipoprotein, Metabolic and Amino Acid Data Reveals a Multi-organ Pathological Signature of SARS-CoV-2 Infection

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Published: 4 August 2020

Dietary metabolite profiling brings new insight into the relationship between nutrition and metabolic risk

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Published: 17 July 2020

Identifying unknown metabolites using NMR-based metabolic profiling techniques

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Published: 17 July 2020

Dietary metabotype modelling predicts individual responses to dietary interventions

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