Changing lives and solving problems of global significance
The work of the ANPC supports almost every area of bioscience. It reaches across traditional research silos and fosters a new, more collaborative approach to science that is critical to solving some of the world’s most challenging problems.
As the international centre of expertise in metabolic phenotyping, the ANPC provides an important new platform for research across the full spectrum of health, food and the environment.
News from the Institute
Core research areas
Precision medicine
Phenomics will enable doctors to deliver precision medicine by predicting the likelihood of disease or characterising its progression, ensuring patients receive treatments tailored to their need.
By studying the phenotypes of different populations, researchers will learn more about the causes and best treatments for a range of complex diseases such as diabetes, autism, antimicrobial resistance to antibiotics, and cancer.
Indigenous health
Phenomics studies will help researchers better understand genetic, dietary, environmental and lifestyle factors that contribute to poorer health outcomes in Aboriginal communities.
This research will help develop and assess the effectiveness of interventions to address these factors and strengthen the health of the population.
Precision Nutrition and Food
Our analysis of population samples will reveal how human health is affected by the nutritional quality and density of food, which will lead the development of nutritional and clinical stratification frameworks through the study of gut microbiome-host-diet interactions.
We are collaborating with researchers around the world to better understand individual responses to diet by coupling data from highly-controlled dietary studies with deep metabolic phenotyping, with the aim of personalizing healthy eating advice.
Excellence in research: Our people
Professor Jeremy Nicholson
An internationally-renowned pioneer in metabolic phenotyping and systems medicine, Professor Nicholson is the Pro Vice Chancellor for Health Sciences at Murdoch University and a Clarivate Analytics Highly Cited Researcher who has authored more than 700 peer-reviewed papers on molecular aspects of body systems medicine.
A Fellow of the UK Academy of Medical Science, Professor Nicholson comes to WA from Imperial College London where he was the founding director of the MRC-NIHR National Phenome Centre.
Professor Elaine Holmes
A distinguished computational biologist, Professor Holmes is Director of the Centre for Computational and Systems Medicine and Deputy Director of the ANPC.
As the Western Australian Premier’s Fellow for Phenomics and Australian Laureate Fellow, Professor Holmes pioneers computational approaches to biomarker discovery by integrating multi-modal data associated with gene-environment interactions.
She is progressing research on maternal and infant health, liver and gastrointestinal disease and metabolic diseases such as diabetes and dementia.
A guide to phenomes and phenomics
Phenome
A person's phenome is a dynamic fingerprint of their unique biology resulting from the complex interactions between environmental and genetic factors.
Phenomics
Phenomics is the study of how a person’s lifestyle and environment interacts with their genes to influence their health and risk of disease.
Metabolic phenotyping
Metabolic phenotyping is the analysis of biological tissue and fluid to uncover the specific interactions of genetic, environmental and lifestyle factors at the molecular level.
The Australian National Phenome Centre is revolutionising the diagnosis, prevention and treatment of disease
Recent Papers
Published: 17 July 2020
Dietary metabotype modelling predicts individual responses to dietary interventions
Published: 4 August 2020
Dietary metabolite profiling brings new insight into the relationship between nutrition and metabolic risk
Published: 17 August 2020
Integrative Modelling of Quantitative Plasma Lipoprotein, Metabolic and Amino Acid Data Reveals a Multi-organ Pathological Signature of SARS-CoV-2 Infection
Published: 20 August 2020
Improved Spatial Resolution of Metabolites in Tissue Biopsies Using High-Resolution Magic-Angle-Spinning Slice Localization NMR Spectroscopy
Published: 27 August 2020
Quantitative In-Vitro Diagnostic NMR Spectroscopy for Lipoprotein and Metabolite Measurements in Plasma and Serum: Recommendations for Analytical Artefact Minimization with Special Reference to COVID-19/SARS-CoV-2 Samples
PUBLISHED: 11 JANUARY 2021