Facilities - banner

Researcher Profiles

Dr Joel Gummer, Research Fellow

Joel is an early-career researcher focused on the application of high-resolution instrumentation to the study of metabolites and peptides in complex biological systems. His wide-ranging research interests include the application of metabolomics to study amphibious host response to chytridiomycosis, a fungal infection of frogs, as well as investigating free fatty acids as predictive biomarkers for Alzheimer’s disease.

One of the projects Joel is leading involves the development of a novel assay for the quantitation of the human peptide hormone hepcidin. Hepcidin, a liver-expressed peptide and central regulator of iron homeostasis in animals, is being increasingly recognised as a key diagnostic marker, with its measurement likely more relevant than traditional measures of iron metabolism to numerous disease diagnoses. Using the Waters Synapt G2-S Imaging mass spectrometer, Joel was able to develop a highly-reproducible and accurate method to quantitate endogenous hepcidin in human plasma. He is now working with research collaborators to provide a testing service at the national level.

Expertise: High resolution MS, untargeted metabolomics, hepcidin biomarker, mass spectrometry imaging.

Ms Hayley Abbiss, Post-Doctoral Research Fellow

Hayley is a post-doctoral research fellow within the Premier's Agriculture and Food Fellowship Program at Murdoch University and Curtin University's Centre for Digital Agriculture. Hayley graduated with first class Honours from Edith Cowan University majoring in applied and analytical chemistry and environmental management. She recently completed a metabolomics based PhD at Murdoch University in the Separation Science and Metabolomics laboratory. Her research is centred on applying metabolomics to detection anf management of stress in agricultural systems and quality assessment of produce. Hayley brings to the group expertise in analytical chemistry and development knowledge in the software for mass spectrometry-based metabolomics applications.

Expertise: Data analysis, analytical chemistry, untargeted metabolomics, agriculture, grain quality.

Shabri Nambiar, PhD Student

An international student from Malaysia, Shabri graduated with a first class Honours in Biomedical Science for his thesis dissertation entitled “An investigation of quinolizidine alkaloids from Lupinus angustifolius as potential therapeutic compounds for Alzheimer’s Disease”. During his Honours studies, Shabri developed a GC-MS/MS method for the quantification of quinolizidine alkaloids in Australian sweet lupins. Plant-derived alkaloids are secondary metabolites known to inhibit the action of acetylcholinesterase (AChE) in neuromuscular junctions, resulting in an increase of acetylcholine, and consequently, enhanced stimulation of postsynaptic cholinergic receptors. While toxic, some of the more successful drugs approved for the treatment of Alzheimer’s disease are plant-derived alkaloids. Using a SH-SY5Y cell-culture model and an AChE-inhibition assay, Shabri was able to demonstrate the potential of quinolizidine alkaloids as potential drug candidates for the development of new Alzheimer’s therapeutics.

Shabri was recently awarded a prestigious Murdoch International Post-graduate Scholarship to investigate idiopathic lung fibrosis from a novel biochemical perspective using mass spectrometry imaging. Using intact fibrotic tissues, he will employ MALDI and DESI-MSI to simultaneously localize and quantify unique molecular signatures in different histopathological regions of interest.

Expertise: Idiopathic lung fibrosis, untargeted metabolomics, mass spectrometry imaging.

Katherine Roussety, Research Officer

Katherine is the Project Officer for the Separation Science and Metabolomics laboratory currently managing the portfolios of projects to ensure timely delivery of outcomes to our research partners. Shortly after graduating from Murdoch University with a degree in Molecular Biology, Biomedical Science and Forensic Toxicology, she commenced her research at SSML using triple quadrupole GC and LC-MS for the targeted analysis of pesticide residues. The in-house method, trademarked “Reschek™” is capable of detecting more than 150 pesticide residues in a single run.

Katherine played a key role in achieving NATA ISO/IEC accreditation for SSML in 2012, as deputy Quality Assurance manager. She has been trained in analytical chemistry and has experience in the implementation of quality systems in accordance with ISO/IEC 17025.

Expertise: NATA ISO/IEC compliance, grain residue testing, method development, high-throughput analysis.