Clinical and Health Focus
The SSML’s clinical and health research is focused on the application of metabolomics technologies and workflow to measure endogenous metabolites within biological systems. In particular, the SSML is using metabolomics to generate unique molecular features and biomarkers that can be measured and evaluated as indicators of disease states.
We are now working on the following:
- Novel quantitative method for the detection of human hepcidin biomarker,
- Assessment of environmental exposure of pesticides in human biofluids,
- Lipidomic profiling for diagnostic development in Alzheimer’s disease,
- Investigation of adulterants in nutraceuticals and traditional therapies,
- Hyperspectral profiling of diseased lung metabolomes using imaging mass spectrometry,
- Pesticide screening of breast milk,
- Metabolic changes in athletes undergoing altitude training and elite performance,
- Development of rapid diagnostics for sepsis.
Agricultural and Plant Research
The SSML is applying high resolution mass spectrometry to agricultural and plant research in the area of trait analysis, disease markers identification, pesticide exposure analysis, food safety and many more. The SSML is using metabolomics to drive the development of new crop varieties by studying the biochemical and cellular mechanisms of plant response to stress including drought, salt tolerance, frost, etc.
Examples of projects we are now spearheading:
- Grain Metabolomics,
- Metabolomics approaches for the dissection of wheat tolerance to herbicides,
- Lipid production in wine grape varieties,
- Novel mycotoxin, phytohormones and alkaloid detection capabilities,
- Plant responses to pest and biotic stress,
- Novel multi-residue test methods for supergrains.
Contract Research and Method Development
The Separation Science and Metabolomics Laboratory has developed a range of validated and in-house methods for gas, liquid and solid samples in human, animal, plant and environmental matrices. Please contact us via Metabolomics@murdoch.edu.au for additional information on our projects and how we can help your research.