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The Research

The main areas of research include:

  1. Broadly neutralising antibody responses to vaccines for control of influenza
  2. Immunoregulation with interferon subtypes
  3. The effect of influenza virus infection on the respiratory tract in early life
  4. Consequences of influenza infection in utero on neonatal development

By understanding the mechanisms that regulate the pathways of the immune response, scientists aim to apply this knowledge to translational immunology with the clinicians of the research group. Innovative approaches in diagnostics and treatment of patients brings hope to prevent diseases and improve good health.

A key area of research is in the field of virus-specific antibody. Antibodies are produced from activated B cells and are important at neutralising extracellular virus and blocking virus replication within cells. Virus can encounter antibody outside the cell or within once internalised. Learning how to make broadly neutralising antibodies that have the ability to bind to different types of influenza viruses is critical for cross-protection and advances towards a universal influenza vaccine. The work of our group is to find out how interferon subtypes can stimulate B cells to produce such broad neutralising antibodies effective against virus subgroups.